Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

@article{Mollinedo2010LipidRA,
  title={Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.},
  author={Faustino Mollinedo and Consuelo Gajate},
  journal={Future oncology},
  year={2010},
  volume={6 5},
  pages={811-21}
}
There is an imperative need to overcome the rather poor outcomes of current cancer chemotherapy with further development of novel targets and drugs. Direct activation of the cancer cell apoptotic machinery constitutes an appealing approach. Recent findings have shown that apoptosis can be triggered by co-aggregation of lipid rafts with death receptors and downstream signaling molecules, thus facilitating their interactions to convey apoptotic signals. We postulate this cluster of apoptotic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Similar Papers

Loading similar papers…