Lipid raft-targeted therapy in multiple myeloma

@article{Mollinedo2010LipidRT,
  title={Lipid raft-targeted therapy in multiple myeloma},
  author={Faustino Mollinedo and Janis de la Iglesia-Vicente and Consuelo Gajate and Ander Estella-Hermoso de Mendoza and J A Villa-Pulgar{\'i}n and Miguel Angel Campanero and Mar{\'i}a J Blanco-Prieto},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={3748-3757}
}
Despite recent advances in treatment, multiple myeloma (MM) remains an incurable malignancy. By using in vitro, ex vivo and in vivo approaches, we have identified here that lipid rafts constitute a new target in MM. We have found that the phospholipid ether edelfosine targets and accumulates in MM cell membrane rafts, inducing apoptosis through co-clustering of rafts and death receptors. Raft disruption by cholesterol depletion inhibited drug uptake by tumor cells as well as cell killing… CONTINUE READING

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