Lipid raft microdomains and neurotransmitter signalling

  title={Lipid raft microdomains and neurotransmitter signalling},
  author={John A. Allen and Robyn A. Halverson-Tamboli and Mark M. Rasenick},
  journal={Nature Reviews Neuroscience},
Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades. The localization of these proteins in lipid rafts, which is affected by the cytoskeleton, also influences the potency and efficacy of neurotransmitter… CONTINUE READING
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