Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor.

@article{Dhanvantari2000LipidRA,
  title={Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor.},
  author={Savita Dhanvantari and Yoke Peng Loh},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 38},
  pages={29887-93}
}
Membrane carboxypeptidase E (CPE) is a sorting receptor for targeting prohormones, such as pro-opiomelanocortin, to the regulated secretory pathway in endocrine cells. Its membrane association is necessary for it to bind a prohormone sorting signal at the trans-Golgi network (TGN) to facilitate targeting. In this study, we examined the lipid interaction of CPE in bovine pituitary secretory granule membranes, which are derived from the TGN. We show that CPE is associated with detergent-resistant… CONTINUE READING

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