Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells.

@article{Salan2005LipidRA,
  title={Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells.},
  author={Christine Sala{\"u}n and Gwyn W. Gould and Luke H Chamberlain},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 20},
  pages={19449-53}
}
SNAP25 and SNAP23 are plasma membrane SNARE proteins essential for regulated exocytosis in diverse cell types. Several recent studies have shown that these proteins are partly localized in lipid rafts, domains of the plasma membrane enriched in sphingolipids, and cholesterol. Here, we have employed cysteine mutants of SNAP25/SNAP23, which have modified affinities for raft domains, to examine whether raft association of these proteins is important for the regulation of exocytosis. PC12 cells… CONTINUE READING