Lipid-protein interaction induced domains: Kinetics and conformational changes in multicomponent vesicles.

  title={Lipid-protein interaction induced domains: Kinetics and conformational changes in multicomponent vesicles.},
  author={K K Sreeja and P B Sunil Kumar},
  journal={The Journal of chemical physics},
  volume={148 13},
The spatio-temporal organization of proteins and the associated morphological changes in membranes are of importance in cell signaling. Several mechanisms that promote the aggregation of proteins at low cell surface concentrations have been investigated in the past. We show, using Monte Carlo simulations, that the affinity of proteins for specific lipids can hasten their aggregation kinetics. The lipid membrane is modeled as a dynamically triangulated surface with the proteins defined as in… 
4 Citations

Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales.

This work discusses the morphological space of nearly planar to highly curved membranes, methods to include thermal fluctuations, and studies that model such proteins as curvature fields to describe the emergent curved morphologies, and discusses several mesoscale models applied to a variety of cellular processes.

Binding of thermalized and active membrane curvature-inducing proteins.

Nonequilibrium dynamics is investigated by the addition of active binding and unbinding at a constant rate and a first-order transition between the U and B phases is found at zero spontaneous curvature driven by the Casimir-like interactions between rigid proteins.

Deformation of an elastic membrane interacting electrostatically with a rigid curved domain: implications to biosystems

Deformation of thin elastic sheet due to electrostatic forces play important role in engineering and biological systems. In this work, we analyze the deformation of thin elastic sheet, while



Interplay between curvature and lateral organization of lipids and peptides/proteins in model membranes.

Using coarse-grained molecular dynamics simulation, this work systematically investigated the interplay between the curvature and lateral sorting of lipids and transmembrane peptides/proteins in the model membranes and confirmed the experimental results of the lateral organization of lipid domains in curved ternary membranes.

Proteins and cholesterol-rich domains.

  • R. Epand
  • Biology
    Biochimica et biophysica acta
  • 2008

Lipid Segregation and Membrane Budding Induced by the Peripheral Membrane Binding Protein Annexin A2*

The results indicate that annexins such as AnxA2 can efficiently induce membrane deformations after lipid segregation, a mechanism possibly underlying annexin functions in membrane trafficking.

Membrane protein sequestering by ionic protein-lipid interactions

The results demonstrate that electrostatic protein–lipid interactions can result in the formation of microdomains independently of cholesterol or lipid phases.

Lateral Organization of Lipids in Multi-component Liposomes

The importance of understanding the equilibrium phase behavior and the kinetics of fluid multicomponent lipid membranes before attempts are made to find the effects of more complex mechanisms that may be involved in the form of lipid rafts is reiterated.