Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4',5'-bisphosphate are both required for ADP-dependent platelet spreading.

@article{Heraud1998LipidPO,
  title={Lipid products of phosphoinositide 3-kinase and phosphatidylinositol 4',5'-bisphosphate are both required for ADP-dependent platelet spreading.},
  author={Jean-Mathias Heraud and Claire Racaud-Sultan and D Gironcel and Corinne Albiges-Rizo and Thea Giacomini and St{\'e}phanie Roques and V{\'e}ronique Martel and Monique Breton-Douillon and Bertrand Perret and Hugues Chap},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 28},
  pages={17817-23}
}
We have shown previously that ADP released upon platelet adhesion mediated by alphaIIb beta3 integrin triggers accumulation of phosphatidylinositol 3',4'-bisphosphate (PtdIns-3,4-P2) (Gironcel, D. , Racaud-Sultan, C., Payrastre, B., Haricot, M., Borchert, G., Kieffer, N., Breton, M., and Chap, H. (1996) FEBS Lett. 389, 253-256). ADP has also been involved in platelet spreading. Therefore, in order to study a possible role of phosphoinositide 3-kinase in platelet morphological changes following… CONTINUE READING
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