Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator

@article{Ajjawi2017LipidPI,
  title={Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator},
  author={Imad Ajjawi and John Verruto and Moena Aqui and Leah Soriaga and Jennifer L. Coppersmith and Kathleen Chun-I Kwok and L. Peach and Elizabeth D. Orchard and Ryan C. Kalb and Weidong Xu and Thomas j. Carlson and Kristie Francis and Katie M Konigsfeld and Judit Bartalis and Andrew Schultz and William Lambert and Ariel S. Schwartz and Robert Brown and Eric R. Moellering},
  journal={Nature Biotechnology},
  year={2017},
  volume={35},
  pages={647-652}
}
Lipid production in the industrial microalga Nannochloropsis gaditana exceeds that of model algal species and can be maximized by nutrient starvation in batch culture. However, starvation halts growth, thereby decreasing productivity. Efforts to engineer N. gaditana strains that can accumulate biomass and overproduce lipids have previously met with little success. We identified 20 transcription factors as putative negative regulators of lipid production by using RNA-seq analysis of N. gaditana… 
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