Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer.

@article{Brindley2004LipidPP,
  title={Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer.},
  author={David N. Brindley},
  journal={Journal of cellular biochemistry},
  year={2004},
  volume={92 5},
  pages={900-12}
}
Lipid phosphates initiate key signaling cascades in cell activation. Lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) are produced by activated platelets. LPA is also formed from circulating lysophosphatidylcholine by autotaxin, a protein involved tumor progression and metastasis. Extracellular LPA and S1P stimulate families of G-protein coupled receptors that elicit diverse responses. LPA is involved in wound repair and tumor growth. Exogenous S1P is a potent stimulator of… CONTINUE READING
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