Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain.

@article{Naka2011LipidPO,
  title={Lipid phenotype of two distinct subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 substrain.},
  author={Takashi Naka and Shinji Maeda and Mamiko Niki and Naoya Ohara and Saburo Yamamoto and Ikuya Yano and Jun-ichi Maeyama and Hisashi Ogura and Kazuo Kobayashi and Nagatoshi Fujiwara},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 51},
  pages={44153-61}
}
Bacillus Calmette-Guérin (BCG) Tokyo 172 is a predominant World Health Organization Reference Reagent for the BCG vaccine. Recently, the BCG Tokyo 172 substrain was reported to consist of two subpopulations with different colony morphologies, smooth and rough. Smooth colonies had a characteristic 22-bp deletion in Rv3405c of the region of difference (RD) 16 (type I), and rough colonies were complete in this region (type II). We hypothesized that the morphological difference is related to lipid… CONTINUE READING
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