Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.

@article{Sultana2013LipidPT,
  title={Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.},
  author={Rukhsana Sultana and Marzia Perluigi and D Allan Butterfield},
  journal={Free radical biology & medicine},
  year={2013},
  volume={62},
  pages={
          157-169
        }
}
Lipid peroxidation involves a cascade of reactions in which production of free radicals occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty acids easily undergo lipid peroxidation chain reactions, which, in turn, lead to the formation of highly reactive electrophilic aldehydes. Among these, the most abundant aldehydes are 4-hydroxy-2-nonenal (HNE) and malondialdehyde, while acrolein is the most reactive. Proteins are susceptible to posttranslational… CONTINUE READING
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