Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress.

@article{Vladykovskaya2012LipidPP,
  title={Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress.},
  author={Elena N Vladykovskaya and Srinivas D. Sithu and Petra Haberzettl and Nalinie S. Wickramasinghe and Michael L Merchant and Bradford G. Hill and James Lyndon McCracken and Abhinav Agarwal and Susan M. Dougherty and Sharon A Gordon and Dale A. Schuschke and Oleg A. Barski and Timothy P. O'Toole and Stanley E. D'Souza and Aruni Bhatnagar and Sanjay Mohan Srivastava},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 14},
  pages={11398-409}
}
Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial activation, and they increase the adhesion of the endothelium to circulating leukocytes. Nevertheless, the mechanisms underlying these effects remain unclear. We observed that in HNE-treated human umbilical vein endothelial cells, some of the protein-HNE adducts colocalize with the endoplasmic reticulum (ER) and that HNE forms covalent adducts with several ER chaperones that assist in protein folding. We… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…