Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes.

@article{Furuno1998LipidPI,
  title={Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes.},
  author={K. Furuno and T. Suetsugu and K. Shimomichi and Y. Tsuruta and N. Sugihara},
  journal={Pharmacology & toxicology},
  year={1998},
  volume={83 4},
  pages={
          176-82
        }
}
  • K. Furuno, T. Suetsugu, +2 authors N. Sugihara
  • Published 1998
  • Biology, Medicine
  • Pharmacology & toxicology
  • Addition of more than 10 microM of adriamycin to cultured rat hepatocytes loaded with alpha-linolenic acid (linolenic acid-loaded hepatocytes) caused marked lipid peroxidation as measured by an accumulation of malondialdehyde during a 9 hr incubation. After addition of 50 microM of adriamycin to linolenic acid-loaded hepatocytes, malondialdehyde accumulation significantly increased at 3 hr, followed by cellular reduced glutathione decrease and lactate dehydrogenase leakage after 6 hr… CONTINUE READING

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