Lipid peroxidation in vivo induced by reversible global ischemia in rat brain.

@article{Watson1984LipidPI,
  title={Lipid peroxidation in vivo induced by reversible global ischemia in rat brain.},
  author={Brant D. Watson and Raul Busto and William J. Goldberg and Mercedes Santiso and Shigeru Yoshida and Myron D. Ginsberg},
  journal={Journal of neurochemistry},
  year={1984},
  volume={42 1},
  pages={268-74}
}
It has been hypothesized that ischemia, followed by reperfusion, facilitates peroxidative free-radical chain processes in brain. To resolve this question, rats were subjected to reversible global ischemia. From coronal sections of brains frozen in situ, small (ca. 2 mg) amounts of tissue were sampled from neocortex, hippocampus, and thalamus of both cerebral hemispheres of four groups of rats exposed to 30 min cerebral ischemia followed by 0, 30, 60, and 240 min of reperfusion, and from a… CONTINUE READING
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