Lipid peroxidation in Alzheimer's disease: emphasis on metal-mediated neurotoxicity.

  title={Lipid peroxidation in Alzheimer's disease: emphasis on metal-mediated neurotoxicity.},
  author={Magisetty Obulesu and R. -C. Venu and R. Somashekhar},
  journal={Acta neurologica Scandinavica},
  volume={124 5},
Despite the crucial role of redox active metals like copper and iron in central biological reactions, their elevated levels are involved in the pathogenesis of Alzheimer's Disease (AD). Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS… CONTINUE READING
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