Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity.

@article{Sivakumar2001LipidPA,
  title={Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity.},
  author={Vivek Sivakumar and J Thanislass and Sivasithambaram Niranjali and Halagowder Devaraj},
  journal={Human & experimental toxicology},
  year={2001},
  volume={20 8},
  pages={398-403}
}
Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalase in liver was reduced, whereas an increase in the activities of superoxide dismutase and glutathione peroxidase was observed. The levels of cytochrome P450, cytochrome b5… CONTINUE READING