Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex.

@article{Gutteridge1984LipidPA,
  title={Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex.},
  author={John M C Gutteridge},
  journal={Biochemical pharmacology},
  year={1984},
  volume={33 11},
  pages={1725-8}
}
In the presence of ferric ions, doxorubicin forms a complex which self-reduces the iron moiety to form a ferrous complex. This ferrous complex can generate active radicals able to degrade deoxyribose as well as form a species greatly stimulatory towards lipid peroxidation. Both reactions may explain the damage to different sites within the body associated with doxorubicin therapy.