Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids.

@article{Austin1996LipidPA,
  title={Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids.},
  author={Erica Weintraub Austin and J M Parrish and David H. Kinder and Richard J. Bull},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={31 1},
  pages={77-82}
}
Chlorinated, brominated, and mixed bromochloro acetates are major by-products of water disinfection by chlorine or ozone. The chlorinated acetates, trichloroacetate (TCA) and dichioroacetate (DCA), are carcinogenic in rodents. Brominated analogs of TCA and DCA have received little study. TCA and DCA induce lipid peroxidation in the livers of rodents when administered acutely. Oxidative stress can also result in oxidative damage to DNA, most commonly measured as increases in 8… CONTINUE READING