Lipid peroxidation accompanies cyclosporine nephrotoxicity: effects of vitamin E.

@article{Wang1995LipidPA,
  title={Lipid peroxidation accompanies cyclosporine nephrotoxicity: effects of vitamin E.},
  author={Chengwei Wang and Abdulla K. Salahudeen},
  journal={Kidney international},
  year={1995},
  volume={47 3},
  pages={927-34}
}
Cyclosporine A (CsA) has been demonstrated to induce renal microsomal lipid peroxidation in vitro. To examine whether CsA induces lipid peroxidation in vivo, uninephrectomized rats were gavaged with vehicle, CsA 12.5 or 25 mg/kg/day for four weeks. CsA-induced reduction in GFR and RBF was associated with a dose-related increase in renal cortical… CONTINUE READING