Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.

@article{George2003LipidPS,
  title={Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.},
  author={Jacob George and Natasha Pera and N. Vo Phung and Isabelle Leclercq and Jing Yun Hou and Geoffrey Farrell},
  journal={Journal of hepatology},
  year={2003},
  volume={39 5},
  pages={756-64}
}
BACKGROUND/AIMS We explored the involvement of cell types, cytokines and lipid peroxidation in a rat dietary model of fibrosing steatohepatitis. METHODS Male rats were fed a high fat diet deficient in methionine and choline (MCD) for up to 17 weeks. Whole liver, hepatocytes and non-parenchymal cells were analysed for reduced glutathione (GSH) levels, products of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), liver injury, and fibrosis. RESULTS MCD diet-fed rats… CONTINUE READING