Lipid peroxidation, iron mobilization and radical generation induced by alcohol.

  title={Lipid peroxidation, iron mobilization and radical generation induced by alcohol.},
  author={Sidney Shaw},
  journal={Free radical biology & medicine},
  volume={7 5},
  • Sidney Shaw
  • Published 1989 in Free radical biology & medicine
Increasing evidence points to a major role for free radicals in the pathogenesis of alcohol-induced liver injury. In vitro, free radicals may be generated during ethanol metabolism by the further metabolism of acetaldehyde by molybdenum-dependent oxidases such as xanthine oxidase. Ferritin iron mobilized by such free radicals may serve as catalytic iron. Increased stores of ferritin iron and induction of microsomal P-450 reductase activity are mechanisms by which chronic alcohol feeding may… CONTINUE READING

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