Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.

@article{Bell2010LipidPI,
  title={Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.},
  author={Jill A. Bell and Melissa A Reed and Leslie A Consitt and Ola J Martin and Kimberly R. Haynie and Matthew W. Hulver and Deborah M. Muoio and Gerald L Dohm},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 7},
  pages={3400-10}
}
CONTEXT Intracellular lipid partitioning toward storage and the incomplete oxidation of fatty acids (FA) have been linked to insulin resistance. OBJECTIVE To gain insight into how intracellular lipid metabolism is related to insulin signal transduction, we examined the effects of severe obesity, excess FA, and overexpression of the FA transporter, FA translocase (FAT)/CD36, in primary human skeletal myocytes. DESIGN, SETTING, AND PATIENTS Insulin signal transduction, FA oxidation, and… CONTINUE READING
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