Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes.

Abstract

Cell membranes are comprised of multicomponent lipid and protein mixtures that exhibit a complex partitioning behavior. Regions of structural and compositional heterogeneity play a major role in the sorting and self-assembly of proteins, and their clustering into higher-order oligomers. Here, we use computer simulations and optical microscopy to study the… (More)
DOI: 10.1073/pnas.1009362108

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