Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia.

@article{Ford2010LipidOB,
  title={Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia.},
  author={David Ford},
  journal={Clinical lipidology},
  year={2010},
  volume={5 6},
  pages={835-852}
}
Leukocytes, containing myeloperoxidase (MPO), produce the reactive chlorinating species, HOCl, and they have important roles in the pathophysiology of cardiovascular disease. Leukocyte-derived HOCl can target primary amines, alkenes and vinyl ethers of lipids, resulting in chlorinated products. Plasmalogens are vinyl ether-containing phospholipids that are abundant in tissues of the cardiovascular system. The HOCl oxidation products derived from plasmalogens are α-chlorofatty aldehyde and… CONTINUE READING

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