Lipid modifications of trimeric G proteins.

  title={Lipid modifications of trimeric G proteins.},
  author={Philip B. Wedegaertner and Paul T. Wilson and Henry R. Bourne},
  journal={The Journal of biological chemistry},
  volume={270 2},
G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide… CONTINUE READING

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