Lipid microarrays identify key mediators of autoimmune brain inflammation

@article{Kanter2006LipidMI,
  title={Lipid microarrays identify key mediators of autoimmune brain inflammation},
  author={Jennifer L. Kanter and Sirisha Narayana and Peggy P-K Ho and Ingrid Catz and Kenneth G. Warren and Raymond A Sobel and Lawrence Steinman and William H Robinson},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={138-143}
}
Recent studies suggest that increased T-cell and autoantibody reactivity to lipids may be present in the autoimmune demyelinating disease multiple sclerosis. To perform large-scale multiplex analysis of antibody responses to lipids in multiple sclerosis, we developed microarrays composed of lipids present in the myelin sheath, including ganglioside, sulfatide, cerebroside, sphingomyelin and total brain lipid fractions. Lipid-array analysis showed lipid-specific antibodies against sulfatide… CONTINUE READING
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