Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats.

  title={Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats.},
  author={James R Levy and B Davenport and John N. Clore and Wayne Stevens},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={282 3},
The interrelationship between insulin and leptin resistance in young Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD) rats were fed regular chow. F344 animals had two- to threefold higher insulin and triglyceride concentrations and increased stores of triglycerides within liver and muscle. F344 animals gained more body fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I gene expression were 20-50% less in F344 animals than in age-matched SD animals… 

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