Lipid membranes modulate the structure of islet amyloid polypeptide.

@article{Jayasinghe2005LipidMM,
  title={Lipid membranes modulate the structure of islet amyloid polypeptide.},
  author={Sajith A Jayasinghe and Ralf Langen},
  journal={Biochemistry},
  year={2005},
  volume={44 36},
  pages={12113-9}
}
The 37-residue islet amyloid polypeptide (IAPP) is thought to play an important role in the pathogenesis of type II diabetes. Despite a growing body of evidence implicating membrane interaction in IAPP toxicity, the membrane-bound form has not yet been well characterized. Here we used circular dichroism (CD) and fluorescence spectroscopy to investigate the molecular details of the interaction of IAPP with lipid membranes of varying composition. In the presence of membranes containing negatively… CONTINUE READING
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