Lipid membranes catalyse the fibril formation of the amyloid-β (1-42) peptide through lipid-fibril interactions that reinforce secondary pathways.


Alzheimer's disease is associated with the aggregation of amyloid-β (Aβ) peptides into oligomers and fibrils. We have explored how model lipid membranes modulate the rate and mechanisms of Aβ(1-42) self-assembly, in order to shed light on how this pathological reaction may occur in the lipid-rich environments that the peptide encounters in the brain. Using… (More)
DOI: 10.1016/j.bbamem.2017.05.012


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