Lipid membranes and beta-amyloid: a harmful connection.

  title={Lipid membranes and beta-amyloid: a harmful connection.},
  author={Gunter P Eckert and Wellington Gibson Wood and Walter E. M{\"u}ller},
  journal={Current protein & peptide science},
  volume={11 5},
Gradual changes in steady-state levels of beta amyloid peptides (Abeta) in the brain are considered as initial step in the amyloid cascade hypothesis of Alzheimer's disease (AD). Abeta is a product of the secretase cleavage of the amyloid precursor protein and there is evidence that the membrane lipid environment may modulate secretase activity and alters its function. Abeta disturbs membrane properties of artificial and isolated biological membranes and of plasma membranes in living cells… CONTINUE READING
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