Lipid mediators in the resolution of inflammation.

  title={Lipid mediators in the resolution of inflammation.},
  author={Charles N Serhan and Nan Chiang and Jesmond Dalli and Bruce David Levy},
  journal={Cold Spring Harbor perspectives in biology},
  volume={7 2},
Mounting of the acute inflammatory response is crucial for host defense and pivotal to the development of chronic inflammation, fibrosis, or abscess formation versus the protective response and the need of the host tissues to return to homeostasis. Within self-limited acute inflammatory exudates, novel families of lipid mediators are identified, named resolvins (Rv), protectins, and maresins, which actively stimulate cardinal signs of resolution, namely, cessation of leukocytic infiltration… CONTINUE READING
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