Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death

@article{Chen2008LipidMI,
  title={Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death},
  author={Minjian Chen and Maziar Divangahi and Huixian Gan and Daniel S.J. Shin and Song Iee Hong and David M Lee and Charles N Serhan and Samuel M Behar and Heinz G. Remold},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={2791 - 2801}
}
Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv and Erdmann depends on predominant LXA(4) production that is part of the antiinflammatory and inflammation-resolving action induced by Mtb. Infection of macrophages with the avirulent H37Ra triggers production of high levels of the prostanoid PGE(2), which promotes… CONTINUE READING
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