Lipid mediators foster the differentiation of T follicular helper cells.

  title={Lipid mediators foster the differentiation of T follicular helper cells.},
  author={Tomonori Nagaya and Keiko Kawata and Ryuta Kamekura and Sumito Jitsukawa and Terufumi Kubo and Motonari Kamei and Noriko Ogasawara and Ken-ichi Takano and Toshiyuki Himi and Shingo Ichimiya},
  journal={Immunology letters},
Lipid mediators such as leukotrienes and lipoxines broadly regulate innate and acquired immunity, and their dysfunction causes various immune-mediated disorders. We previously reported a salient feature of arachidonate 5-lipoxyganase (Alox5), which is responsible for the production of such lipid mediators, in the regulation of high affinity antibodies in vivo. The aim of this study was to determine the functional significance of Alox5-related lipid mediators during the processes of acquired… CONTINUE READING
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