Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

  title={Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence},
  author={Michael J Steinbaugh and Sri Narasimhan and Stacey Robida-Stubbs and Lorenza E Moronetti Mazzeo and Jonathan M. Dreyfuss and John M Hourihan and P Raghavan and Theresa N. Opera{\~n}a and Reza Esmaillie and T. Keith Blackwell},
In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also increases fat accumulation and alters lipid metabolism, raising the intriguing question of how these effects might be related. Here, we show that a lack of GSCs results in a broad transcriptional reprogramming in which the conserved detoxification regulator SKN-1/Nrf increases stress resistance, proteasome activity, and longevity. SKN-1 also activates diverse lipid metabolism genes and reduces fat… CONTINUE READING
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