Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup.

Abstract

A series of amphiphiles with differing cationic tri- and di- peptide headgroups, designed and synthesized based on lysine (K), ornithine (O), arginine (R), and glycine (G), have been characterized and evaluated for DNA and siRNA delivery. DNA-lipoplexes formed from the tri- and di- lipopeptides possessed lipid:nucleic acid charge ratios of 7:1 to 10:1… (More)
DOI: 10.1039/C3SM27633C

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