Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29.

@article{Zhu2015LipidloweringPF,
  title={Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29.},
  author={Mei-lin Zhu and Huquan Gao and Chongming Wu and T. Zhu and Q. Che and Q. Gu and P. Guo and Dehai Li},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 17},
  pages={
          3606-9
        }
}
Two new C12 polyketides, cladospolides E and F (1 and 2), together with four known derivatives seco-patulolides A and C (3 and 4), 11-hydroxy-γ-dodecalactone (5) and iso-cladospolide B (6), were isolated from a soft coral-derived fungus Cladosporium sp. TZP-29. Their structures, including the absolute configurations, were elucidated by spectroscopic analysis, modified Mosher's method, and the analysis of their biogenesis. All compounds were non-cytotoxic while compounds 1 and 3-5 showed potent… Expand
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