Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.

@article{Lee2001LipidloweringAA,
  title={Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.},
  author={Jeongeun Lee and Myung Sook Choi and Seon Min Jeon and Tae Sook Jeong and Yong Bok Park and Mi Kyung Lee and S H Bok},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2001},
  volume={314 1-2},
  pages={221-9}
}
BACKGROUND Polyphenols appear to have antioxidant activities and may mediate lipid lowering. METHODS Four groups of rats, a high-cholesterol control (HC), HC+lovastatin, HC+3,4-di(OH)-cinnamate, and HC+3,4-di(OH)-hydrocinnamate, were given a semi-synthetic diet. The cinnamate derivative or lovastatin (0.1 g/100 g) supplements were given for 6 weeks. RESULTS The plasma total cholesterol concentration was significantly lowered by the 3,4-di(OH)-cinnamate supplement compared to the control or… CONTINUE READING

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