Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.

  title={Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.},
  author={J. S. H. Lee and Myoung Su Choi and Seon-min Jeon and Tae-Sook Jeong and Y. B. Park and M. K. Lee and Song Hae Bok},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={314 1-2},
  • J. Lee, M. Choi, S. Bok
  • Published 1 December 2001
  • Biology
  • Clinica chimica acta; international journal of clinical chemistry
Effect of 3,4‐di(OH)‐cinnamate synthetic derivative on plasma and hepatic cholesterol level and antioxidant enzyme activities in high cholesterol‐fed rats
Results suggest that SL‐1063, a synthetic derivative of 3,4‐di(OH)‐cinnamate, is effective in lowering the plasma lipids and improving the antioxidant enzyme system.
4-Hydroxycinnamate Lowers Plasma and Hepatic Lipids without Changing Antioxidant Enzyme Activities
Results indicate that 4-(OH)-C was effective in lowering the plasma cholesterol and hepatic lipids in rats fed a high-cholesterol diet.
Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats.
Dietary cinnamate inhibits hepatic HMG-CoA reductase activity, resulting in lower hepatic cholesterol content, and suppresses lipid peroxidation via enhancement of hepatic antioxidant enzyme activities.
Lipid‐lowering efficacy of 3,4‐di(OH)‐phenylpropionic L‐leucine in high‐cholesterol fed rats
Results indicate that PPLA, a leucine‐attached version of HC, exhibited a similar significant hypocholesterolemic effect to HC in rats fed a high‐cholesterol diet.
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.
Attenuation of Atherosclerosis by 3,4-Dihydroxy- Hydrocinnamic Acid in Rabbits by Partial Inhibition of ACAT
Results indicate that 3,4-DHHCA had antiatherogenic effects in rabbits, possibly by partial inhibition of ACAT.


Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids.
The inhibition of HMG-CoA reductase and ACAT activities resulting from the supplementation of either tangerine-peel extract or a combination of its bioflavonoids could account for the decrease in fecal neutral sterol that appears to compensate for the decreased cholesterol biosynthesis in the liver.
Effect of ethyl esterification of phenolic acids on low-density lipoprotein oxidation.
Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids.
The modifying effects of dietary administration of the plant phenolic antioxidants caffeic acid (CA), ellagic acid (EA), chlorogenic acid (CGA) and ferulic acid (FA) during the initiation phase on
Effect of caffeic acid dietary supplementation on the antioxidant defense system in rat: an in vivo study.
The results demonstrate the physiological relevance of caffeic acid and its antioxidant action in vivo, through both a direct contribution to the antioxidant defense system and a sparing effect on alpha-tocopherol.
Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A.
A new assay for 3-hydroxy-3-methylglutaryl CoA reductase (mevalonate:NADP oxidoreductase [acylating CoA], EC is based upon the measurement of released coenzyme A (SH) during the reduction
Enzymic determination of 3 alpha-, 7 alpha-, and 12 alpha-hydroxyl groups of fecal bile salts.
The authors used microbial 3 alpha, 7 alpha, and 12 alpha-hydroxysteroid dehydrogenases to quantify 3 alpha-, 7 alpha-, and 12alpha-hydroxyl groups in human feces to quantify three group-specific hydroxysteroid dehydration preparations.