Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

@article{Stoyanova1997LipidKA,
  title={Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.},
  author={Stefka Stoyanova and G Bulgarelli-Leva and Cornelia Kirsch and Theodor Hanck and Reinhard Klinger and Reinhard Wetzker and Matthias P Wymann},
  journal={The Biochemical journal},
  year={1997},
  volume={324 ( Pt 2)},
  pages={489-95}
}
Signalling via seven transmembrane helix receptors can lead to a massive increase in cellular PtdIns(3,4,5)P3, which is critical for the induction of various cell responses and is likely to be produced by a trimeric G-protein-sensitive phosphoinositide 3-kinase (PI3Kgamma). We show here that PI3Kgamma is a bifunctional lipid kinase and protein kinase, and that both activities are inhibited by wortmannin at concentrations equal to those affecting the p85/p110alpha heterodimeric PI3K (IC50 approx… CONTINUE READING

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