Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.

@article{Magnan1999LipidIL,
  title={Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose.},
  author={Christophe Magnan and Stephan Collins and Marcel Berthault and Nadim Kassis and Myl{\`e}ne Vincent and Marc Gilbert and Luc P{\'e}nicaud and Alain Ktorza and Françoise Assimacopoulos-Jeannet},
  journal={The Journal of clinical investigation},
  year={1999},
  volume={103 3},
  pages={413-9}
}
We investigated the possible involvement of the autonomic nervous system in the effect of a long-term elevation of plasma free fatty acid (FFA) concentration on glucose-induced insulin secretion (GIIS) in rats. Rats were infused with an emulsion of triglycerides (Intralipid) for 48 hours (IL rats). This resulted in a twofold increase in plasma FFA concentration. At the end of infusion, GIIS as reflected in the insulinogenic index (DeltaI/DeltaG) was 2.5-fold greater in IL rats compared with… CONTINUE READING