Lipid-induced mitochondrial stress and insulin action in muscle.

  title={Lipid-induced mitochondrial stress and insulin action in muscle.},
  author={Deborah M. Muoio and P. Darrell Neufer},
  journal={Cell metabolism},
  volume={15 5},
The interplay between mitochondrial energetics, lipid balance, and muscle insulin sensitivity has remained a topic of intense interest and debate for decades. One popular view suggests that increased oxidative capacity benefits metabolic wellness, based on the premise that it is healthier to burn fat than glucose. Attempts to test this hypothesis using genetically modified mouse models have produced contradictory results and instead link muscle insulin resistance to excessive fat oxidation… CONTINUE READING