Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

@article{Holland2011LipidinducedIR,
  title={Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.},
  author={William L Holland and Benjamin T Bikman and Liping Wang and Guan Yuguang and Katherine M Sargent and Sarada Bulchand and Trina A. Knotts and Guanghou Shui and Deborah J. Clegg and Markus R. Wenk and Michael J. Pagliassotti and Phillip E Scherer and Scott A. Summers},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 5},
  pages={1858-70}
}
Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One mechanism accounting for the increased inflammation associated with obesity is activation of the innate immune signaling pathway triggered by TLR4 recognition of saturated fatty acids, an event that is essential for lipid-induced insulin resistance. Using in vitro and in vivo systems to model lipid induction of TLR4… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
200 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 200 extracted citations

Similar Papers

Loading similar papers…