Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL.

@article{Kashyap2009LipidinducedIR,
  title={Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL.},
  author={Sangeeta R. Kashyap and Adriana Gabriela Ioachimescu and Heather L Gornik and Thottathil Gopan and Michael B. Davidson and Antonie Makdissi and Jennifer I Major and Maria Febbraio and Roy L Silverstein},
  journal={Obesity},
  year={2009},
  volume={17 12},
  pages={2142-8}
}
Elevated free fatty acids (FFAs) contribute to the development of insulin resistance, type 2 diabetes mellitus (T2DM), and may be atherogenic. We tested the relationship among lipid-induced insulin resistance, endothelial dysfunction, and monocyte capacity to form foam cells through scavenger receptor A (SRA) and CD36. Ten healthy subjects underwent 24-h infusion of Intralipid/heparin and saline (0.5 ml/min) on two separate occasions followed by brachial artery reactivity testing and a… CONTINUE READING

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Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society • 2008

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