Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

@article{Goh2007LipidinducedBD,
  title={Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.},
  author={Tracy T Goh and Timothy M Mason and Neehar Gupta and Abby So and Tony K. T. Lam and Loretta Lam and Gary F. Lewis and Andrea Mari and Adria Giacca},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 2},
  pages={E549-60}
}
We determined the effect of 48-h elevation of plasma free fatty acids (FFA) on insulin secretion during hyperglycemic clamps in control female Wistar rats (group a) and in the following female rat models of progressive beta-cell dysfunction: lean Zucker diabetic fatty (ZDF) rats, both wild-type (group b) and heterozygous for the fa mutation in the leptin receptor gene (group c); obese (fa/fa) Zucker rats (nonprediabetic; group d); obese prediabetic (fa/fa) ZDF rats (group e); and obese (fa/fa… CONTINUE READING

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