Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.

Abstract

Macrophage activation is characterized by pronounced metabolic adaptation. Classically activated macrophages show decreased rates of mitochondrial fatty acid oxidation and oxidative phosphorylation and acquire a glycolytic state together with their pro-inflammatory phenotype. In contrast, alternatively activated macrophages require oxidative phosphorylation… (More)
DOI: 10.1111/imm.12844

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Cite this paper

@article{Geric2018LipidHA, title={Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.}, author={Ivana Geric and Yulia Y. Tyurina and Olga L Krysko and Dmitri V Krysko and Evelyn de Schryver and Valerian E Kagan and Paul P Van Veldhoven and Myriam Baes and Simon Verheijden}, journal={Immunology}, year={2018}, volume={153 3}, pages={342-356} }