PURPOSE The Dixon techniques provide uniform water-fat separation but require multiple image sets, which extend the overall acquisition time. Here, an alternative rapid single acquisition method, lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA), was introduced. METHODS The LEENA method utilized a fast imaging with steady-state free precession sequence to obtain a single k-space dataset in which successive k-space lines are acquired to allow the fat magnetization to precess 180°. The LEENA data were then unghosted using either image-domain (LEENA-S) or k-space domain (LEENA-G) parallel imaging techniques to reconstruct water-only and fat-only images. An off-resonance correction technique was incorporated to improve the uniformity of the water-fat separation. RESULTS Uniform water-fat separation was achieved for both the LEENA-S and LEENA-G methods for phantom and human body and leg imaging applications at 1.5T and 3T. The resultant water and fat images were qualitatively similar to conventional 2-point Dixon and fat-suppressed images. CONCLUSION The LEENA-S and LEENA-G methods provide uniform water and fat images from a single MRI acquisition. These straightforward methods can be adapted to 1.5T and 3T clinical MRI scanners and provide comparable fat/water separation with conventional 2-point Dixon and fat-suppression techniques.