Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies.

@article{Neupane2013LipidDC,
  title={Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies.},
  author={Yub Raj Neupane and Moin ud Din Sabir and Nafees Ahmad and Md.Farhad Ali and Gurpreet Kaur Kohli},
  journal={Nanotechnology},
  year={2013},
  volume={24 41},
  pages={
          415102
        }
}
The purpose of this study was to develop lipid drug conjugate (LDC) nanoparticles of decitabine (DCB) using stearic acid as a lipid to increase the permeability of the drug along with its protection from chemical degradation. The LDC was prepared by salt formation of DCB with stearic acid and followed by cold homogenization technique to produce the LDC nanoparticles. The role of key independent variables influencing on dependent variables were determined by using a Box-Behnken design. The… CONTINUE READING
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