Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis

@article{Straub2010LipidDP,
  title={Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis},
  author={Beate Katharina Straub and Esther Herpel and Stephan Singer and R. K. Zimbelmann and Kai Breuhahn and Stephan Macher-Goeppinger and Arne Warth and Judith Lehmann-Koch and Thomas Longerich and Hans L. Heid and Peter Schirmacher},
  journal={Modern Pathology},
  year={2010},
  volume={23},
  pages={480-492}
}
In many human cancers, lipogenic pathways are activated; in some tumors, such as hepatocellular carcinoma, this is reflected by the presence of visible lipid droplets. Yet, the biology of steatogenesis in malignant tumors is largely unknown. We have recently shown that lipid droplet-associated proteins of the PAT-family, named after their constituents perilipin (perilipin 1), adipophilin (perilipin 2), and TIP47 (perilipin 3) are differentially expressed in hepatic steatogenesis. We have… CONTINUE READING
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