Lipid domain coarsening and fluidity in multicomponent lipid vesicles: A continuum based model and its experimental validation

  title={Lipid domain coarsening and fluidity in multicomponent lipid vesicles: A continuum based model and its experimental validation},
  author={Y Wang and Yerbol Palzhanov and Annalisa Quaini and Maxim A. Olshanskii and Sheereen Majd},
  journal={Biochimica et biophysica acta. Biomembranes},

A comparison of Cahn-Hilliard and Navier-Stokes-Cahn-Hilliard models on manifolds

An unfitted finite element method is applied that is flexible in handling complex and possibly evolving shapes in the absence of an explicit surface parametrization for the numerical simulation of lateral phase separation and coarsening in lipid membranes.



Dynamics of coarsening in multicomponent lipid vesicles with non-uniform mechanical properties.

This work investigates the dynamics of phase separation in multicomponent lipid vesicles, using a model that couples composition to mechanical properties such as bending rigidity and spontaneous curvature.

Coarsening dynamics of domains in lipid membranes.

Giant unilamellar vesicles - a perfect tool to visualize phase separation and lipid rafts in model systems.

The use of GUVs in studying lipid phase separation and the appearance and behavior of lipid domains (rafts) in membranes is discussed but also other examples ofGUVs use in membrane research are given.

Floret-shaped solid domains on giant fluid lipid vesicles induced by pH.

Fluorescence microscopy on giant unilamellar fluid vesicles (GUVs) shows that lowering pH promotes condensation of titratable PS or PA lipids into beautiful floret-shaped domains in which lipids are tightly packed via hydrogen-bonding and van der Waals interactions.

The molecular face of lipid rafts in model membranes

A simulation model is applied to assess the molecular nature of domains formed in ternary mixtures, showing the spontaneous separation of a saturated phosphatidylcholine (PC)/unsaturated PC/cholesterol mixture into a liquid-ordered and aLiquid-disordered phase with structural and dynamic properties closely matching experimental data.

Phase-field modeling of the dynamics of multicomponent vesicles: Spinodal decomposition, coarsening, budding, and fission.

A thermodynamically consistent phase-field model to simulate the dynamics of multicomponent vesicles and finds differences between the spontaneous curvatures and the bending rigidities of the surface phases are found numerically to lead to the formation of buds, asymmetric vesicle shapes andvesicle fission even in two dimensions.