Lipid-dependent membrane protein topogenesis.

  title={Lipid-dependent membrane protein topogenesis.},
  author={William Dowhan and Mikhail Bogdanov},
  journal={Annual review of biochemistry},
The topology of polytopic membrane proteins is determined by topogenic sequences in the protein, protein-translocon interactions, and interactions during folding within the protein and between the protein and the lipid environment. Orientation of transmembrane domains is dependent on membrane phospholipid composition during initial assembly as well as on changes in lipid composition postassembly. The membrane translocation potential of negative amino acids working in opposition to the positive… CONTINUE READING